Ictal Swearing as a Lateralizing Value for the Dominant Hemisphere in Temporal Lobe Epilepsy

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Abstract

Introduction

Ictal swearing, a culturally taboo offensive utterance1 is a rare manifestation in epilepsy patients,2–4 and its pathophysiology and localizing value of ictal swearing are unclear, although a variety of automatisms, including ictal speech, are lateralizing signs for the non-dominant hemisphere.1–5 Herein, we report a patient with ictal swearing, with ictal discharges on the temporal lobe of the dominant hemisphere, confirmed by video electroencephalography (EEG) monitoring.

Case Report

A 41-year-old right-handed man presented with episodes of ictal swearing with loss of consciousness lasting for approximately 1 minute and occurring mostly during daytime naps at his workplace. These stereotypic episodes had started 2 months before his visit to the epilepsy clinic. He had no other significant medical history, including perinatal complications, febrile convulsions, central nervous system infections or trauma, or a family history of epilepsy.

During the 3 days of scalp video-EEG monitoring (VEM), three episodes of stereotypic seizures were recorded. Each ictal episode lasted for approximately 1 minute, and the longest was approximately 2 minutes. The seizures started with sudden awakening, followed by stereotypical swearing with “ssibal” (“fuck” in Korean) (Supplementary Videos 1, 2). Ictal discharges of the VEM revealed that rhythmic theta activities started from the left temporal region and propagated to the left hemisphere with semi-rhythmic delta activities (Fig. 1A). T2 fluid-inversion recovery (FLAIR) brain magnetic resonance imaging (MRI) showed high signal intensity in the left amygdala (Fig. 1B). The patient was diagnosed with epilepsy but was seizure-free during the 8-month follow-up period after taking oxcarbazepine at 1,200 mg/day.

Figure 1

(A) Ictal discharge started with theta activities from the left temporal area (blue arrow), followed by rhythmic delta activities in the left hemisphere. (B) Coronal sections of a T2 fluid-inversion recovery magnetic resonance imaging scan revealed a high signal intensity in the left amygdala (yellow arrow).

Discussion

Ictal swearing is more common among males, with lateralization to the non-dominant hemisphere.2,4,6 However, Massot-Tarrús et al.1 reported that five out of nine subjects were women, and the lateralizing value of the seizures was unclear. At the onset of swearing, ictal EEG activities were localized to the mesial temporal or orbitofrontal regions in all patients, regardless of the hemispheric side,1,5 which was consistent with our case. Although ictal speech has a lateralizing value for non-dominant hemispheric seizures, our case with ictal swearing revealed an epileptic focus in the dominant hemisphere.

Ictal swearing is a verbal automatism associated with negative emotion,3 whereas ictal speech is characterized by comprehensible speech.4 This implies a different neurophysiological process between ictal swearing and ictal speech.2,5 Ictal speech results from activation or inhibition of language cortical function, whereas the hypothesized mechanism of ictal swearing is the dysregulation of emotional and behavioral function.4 In this context, limbic frontal-temporal networks can produce ictal swearing.1,3 The orbitofrontal cortex (OFC) receives inputs from all sensory modalities, including the amygdala, hippocampus, cingulate cortex, and projects back to the temporal lobe area.3,4 The inhibitory connection from the OFC to the amygdala regulates negative emotions and related behaviors.1,3

In our patient, FLAIR MRI showed a high signal intensity in the left amygdala, which is thought to be a seizure-related change. Despite the lack of further imaging studies, including functional MRI, considering all the findings of symptomatic semiology, ictal EEG discharges, and MRI scans, the amygdala might be an important candidate for the pathophysiological mechanism of ictal swearing. Our case provides evidence for a possible neurophysiological process of ictal swearing. Further neuroimaging studies, including functional MRI and positron emission tomography, should be conducted to clarify the underlying mechanism.

To the best of our knowledge, this is the first case report of repetitive ictal swearing originating from the dominant hemisphere, which was concordantly localized by VEM recording and MRI findings. Our case showed that a detailed history of the presence of stereotypy of ictal events could improve diagnostic accuracy for epilepsy and reduce the probability of misdiagnosis of vocal tics or violent profanity.

Supplementary materials

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