Cannabinoids in the Treatment of Epilepsy: Hard Evidence at Last?
Emilio Perucca
J Epilepsy Res. 2017;7(2):61-76.   Published online 2017 Dec 31     DOI: https://doi.org/10.14581/jer.17012
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Sabrina Rahman Archie, Luca Cucullo
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Tyler E. Gaston, Jerzy P. Szaflarski
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Gabriele Ruffolo, Pierangelo Cifelli, Cristina Roseti, Maria Thom, Erwin A. van Vliet, Cristina Limatola, Eleonora Aronica, Eleonora Palma
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Seizure.2018; 63: 17.     CrossRef