1. Roy MK, Das D. Indian Guidelines on Epilepsy. Chapter 116. Section 16: Neurology Medicine Update 2013.. The Association of Physician of India; Retrieved from: http://www.apiindia.org/medicine_update_2013/chap116.pdf (Accessed August 2014)..
2. Kounteya S. Around 95% of Indian with epilepsy don’t get treatment study. The Times of India; Retrieved from: http://timesofindia.indiatimes.com/india/Around-95-of-Indians-with-epilepsy-dont-get-treatment-Study/articleshow/16585514.cms (Accessed August 2014)..
3. Andlin-Sobocki P, Jonss B, Wittchen HU, Olesen J. Cost of disorders of the brainin Europe. Eur J Neurol. 2005;12:1–27.
4. Majkowski J, Majkowska-Zwolińska B. Direct and Indirect Annual Costs of Patients with Epilepsy in Poland-Prospective Multicenter Study. Epileptologia. 2010;18:141–52.
5. Leonardi M, Ustrun TB. The global burden of epilepsy. Epilepsia. 2002;43:21–5.
6. Brodtkorb E, Nakken KO. The relationship between epilepsy and religiosity illustrated by the story of the visionary mystic Wise-Knut. Epilepsy & Behavior. 2015;46:99–102.
7. Giovagnoli AR, Meneses RF, Da Silva AM. The contribution of spirituality to quality of life in focal epilepsy. Epilepsy & Behavior. 2006;9:133–9.
8. Işler A, Turan FD, Gozum S, Oncel S. Complementary and alternative approaches used by parents of children with epilepsy on epilepsy management. Epilepsy & Behavior. 2014;32:156–161.
9. Tewary R, Mishra JK. Hawan. An effective method to reduce fungal load at small work places. Aerobiologia. 1997;13:135–8.
10. Nigam R, Hashimi NH. Has sea level fluctuations modulated human settlements in gulf of Khambat (Cambay)? Journal of Geological Society of India. 2002;59:583–4.
11. Mleccha Kalyanraman S. Indus script and sarasvati hieroglyphs. Bangalore: Baba Saheb (Umakanta Keshava) Apte Smarak Samiti; 2004.
12. Jain S, Tandon PN. Ayurvedic medicine and Indian literature on epilepsy. Neurology Asia. 2004;9:57–58.
13. Fischer JH. The epilepsy counseling guide. New Jersey: MPE Communications Inc; 1994.
14. Garnett WR. Epilepsy. Stamford, CT: Appleton and Lange; 1997. p. 1179–210.
15. Frantseva MV, Perez Velazquez JL, Tsoraklidis G, et al. Oxidative stress is involved in seizure-induced neurodegeneration in the kindling model of epilepsy. Neuroscience. 2000;97:431–3.
16. Frantseva MV, Perez Velazquez JL, Carlen PL. Changes in membrane and synaptic properties of thalamocortical circuitry caused by hydrogen peroxide. J. Neurophysiol. 1998;80:1317–26.
20. Sullivan PG, Springer JE, Hall ED, Scheff S. Mitochondrial uncoupling as a therapeutic target following neuronal injury. J. Bioenerg Biomembr. 2004;36:353–6.
22. Majkowski J. Epileptogenesis-The role of oxygen stress. Epileptologia. 2007;1:225–40.
25. Scorer CA. Preclinical and clinical challenges in the development of disease-modifying therapies for Alzheimer's disease. Drug Discov Today. 2001;6:1207–19.
26. Blennow K, de Leon MJ, Zetterberg H. Alzheimer’s disease. Lancet. 2006;368:387–403.
27. Tripathi KD. Essentials of medical pharmacology. New Delhi: JP Brothers Medical Published; 2010.
28. Keikelame MJ, Swartz L. A thing full of stories’: Traditional healers’ explanations of epilepsy and perspectives on collaboration with biomedical health care in Cape Town. Transcultural Psychiatry. 2015;10.1177/1363461515571626.
29. Kishore J, Gupta A, Jiloha RC, Bantman P. Myth, beliefs and perceptions about mental disorders and health seeking behavior in Delhi, India. Indain J Psychiatry. 2011;53:324–9.
30. Turker S, Onur E, Ozer Y. Nasal route and drug delivery systems. Pharm World Sci. 2004;26:137–42.
31. Sugawara Y, Hara C, Aoki T, Sugimoto N, Masujima T. Odor distinctiveness between enantiomers of linalool: difference in perception and responses elicited by sensory test and forehead surface potential wave measurement. Chem Senses. 2000;25:77–84.
32. Guedes DN, Silva DF, Barbosa-Filho JM, Medeiros IA. Muscarinic agonist properties involved in the hypotensive and vasorelaxant responses of rotundifolone in rats. Planta Med. 2002;68:700–4.
33. Nagai M, Wada M, Usui N, Tanaka A, Hasebe Y. Pleasant odors attenuate the blood pressure increase during rhythmic handgrip in humans. Neuroscience Letters. 2000;289:227–9.
34. Ballard CG, Gauthier S, Cummings JL, et al. Management of agitation and aggression associated with Alzheimer disease. Nat Rev Neurol. 2009;5:245–55.
35. Turker S, Onur E, Ozer Y. Nasal route and drug delivery systems. Pharm World Sci. 2004;26:137–42.
36. Ghadrdoost B, Vafaei AA, Rashidy-Pour A, Hajisoltani R, Bandegi AR, Motamedi F, et al. Protective effects of saffron extract and its active constituent crocin against oxidative stress and spatial learning and memory deficits induced by chronic stress in rats. Eur J Pharmacol. 2011;667:222–9.
37. Reddy PM, Gobinath M, Rao KM, Venugopalaiah P, Reena N. A Review on Importance of Herbal Drugs in Cosmetics. International Journal of Advances in Pharmacy and Nanotechnology. 2011;1:121–39.
39. Makhija IK, Sharma IP, Khamar D. Phytochemistry and Pharmacological properties of Ficus religiosa: An overview. Annals of Biological Research. 2010;1:171–80.
40. Borhade P, Tankar A, Joshi S, Khandelwal K. Pharmacological Review on Ficus Racemosa Linn. IJPRBS. 2012;1:51–66.
41. Neelakanth MJ, Bhat MR, Taranalli AD, Veeresh B. Effect of Buchanania lanzan Seeds on Learning and Memory in Normal and Memory Deficit Rats. Journal of Researchers in Pharmabiomedica. 2012;22:33–8.
42. Sharma S, Sharma J, Kaur G. Therapeutic uses of Elettaria cardomum. International Journal of Drug Formulation and Research. 2011;2:102–8.
44. Joshi RR. The Integrated Science of Yagna. http://literature.awgp.org/magazine/Akhand-Jyoti-english/2003/MarApr/ScientificAspectsofYajna..
45. Katariya DC, Nerkar N, Gadiya RV, Abhyankar MM. Detailed Profile of Crocus Sativus. International Journal of Pharma And Bio Sciences. 2011;2:530–40.
46. Sunanda BPV, Rammohan B, Kumar A, Kudagi BL. The Effective Study of Aqueous Extract of Crocus Sativus Linn in Chemical Induced Convulsants in Rats. World Journal of Pharmacy And Pharmaceutical Sciences. 2014;3:1175–82.
47. Hosseinzadeh H, Ghenaati J. Evaluation of the antitussive effect of stigma and petals of saffron (Crocus sativus) and its components, safranal and crocin in guinea pigs. Fitoterapia. 2006;77:446–8.
48. Abe K, Saito H. Effects of saffron extract and its constituent crocin on learning behavior and long-term potentiation. Phytother Res. 2000;14:149–152.
49. Vida JA, Foye WO, Lemke TL, Williams DA. Principles of Medicinal Chemistry. London: Williams and Wilkins; 1995. p. 163–79.
50. Zargari A. Medicinal Plants Tehran. Tehran: University Press; 1990. p. 574–8.
51. Zhang Y, Shoyama Y, Sugiura M, Saito H. Effect of Crocus sativus L. on the ethanol-induced impairment of passive avoidance performances in mice. Biol Pharm Bull. 1994;17:217–21.
52. Sheng L, Qian Z, Zheng S, Xi L. Mechanism of hypolipidemic effect of crocin in rats: Crocin inhibits pancreatic lipase. Eur J Pharmacol. 2006;543:116–222.
53. Bagchi A, Oshima Y, Hikino H. Neoligans and lignans of Nardostachys Jatamansi roots. Planta Med. 1991;57:96–97.
54. Rao VS, Rao A, Karanth KS. Anticonvulsant and neurotoxicity profile of Nardostachys jatamansi in rats. J Ethanopharmacol. 2005;102:351–6.
55. Rucker G, Tautges J, Wenzl H, Graf E. Isolation and pharmacological active its of the sesquiterpene valeranone from Nardostachys jatamansi DC (in Germen). Arzneimittelforschung. 1978;28:7–13.
56. Metkar B, Pal SC, Kasture S. Antiepressant activity of N. jatamansi DC. Indian J Nat Prod. 1999;15:10–3.
57. Prabhu V, Karanth KS, Rao A. Effects of Nardostachys jatamansi on biogenic-amine and inhibitory amino-acids in the rat-brain. Planta Med. 1994;60:114–7.
58. Ha JH, Lee DU, Lee JT, et al. 4- Hydroxybenzaldehyde from Gastrodia elata as active in the anti-oxidation and GABAergic neuromodulation of the rat brain. J Ethnopharmacol. 2000;73:329–33.
59. Ormandy GC, Jope RS, Snead OC. Anticonvulsant actions of MK-801 on the lithium-pilocarpine model of status epilepticus in rats. Exp Neurol. 1989;106:172–80.
60. Sherman WR, Honchar MP, Honsel LY. Detection of receptor linked phosphoinositide metabolism in brain of lithium treated rats. Bleasdale TE, Eichborg J, Hauser C, editors. Inositol and Phosphoinositides: Metabolism and regulation. Clifton NJ: Humana Press; 1989. p. 49–65.
61. Tiwari PK, Irchhaiya R, Jain SK. Evaluation of anticonvulsant activity of Mesua ferrea Linn. ethanolic flower extract. Int. J. Pharm Life Sci. 2012;23:1507–9.
62. Miraghaee SS, Karmi I, Becker LA. Psychobiological Assessment of Smoke of Agarwood (Aquilaria spp.) in Male Rats. 2011;5:45–50.
63. Lovelyn J, Rejeesh EP, Rao SN. Anticonvulsant Activity of Hyrdroethanolic Extract of Valeriana Wallichii Root on Maximal Electroshock Induced Seizure Model in Swiss Albino Mice. International Journal of Universal Pharmacy and Bio Sciences. 2013;2:66–70.
64. Murali A, Sudha C, Madhavan V, Yoganarasimhan SN. Anticonvulsant and sedative activity of tagara (Nymphoides macrospermum). Pharmaceutical Biology. 2007;45:407–10.
65. Velmurugan V, Arunachalam G, Ravichandran V. Anticonvulsant Activity of Methanolic Extract Anticonvulsant Activity of Methanolic Extract of Prosopis Cineraria (Linn) Druce Stem Barks. International Journal of Pharm Tech Research. 2012;4:89–92.
66. Kendall DA, Fox DA, Enna SJ. Anticonvulsant profile of gamma vinyl GABA. Neuropharmacology. 1981;20:4–10.
67. Nicoll RA. Introduction to the pharmacology of CNS drugs. San Fransisco: McGraw-Hill Medical; 2007. p. 333–46.
68. Karangwa C, Esters V, Tits M, et al. Characterization of the neurotoxicity induced by extract of Magnistipula butayei (Chrystobalanaceae) in rats: effects of a new natural convulsive agent. Toxicon. 2007;49:1109–19.
69. Lavanya K, Prasada RA, Chakravarthy , Mahendran B. A Review on Biological and Chemical Properties of Cyperus Species. Research Journal of Pharmaceutical, Biological and Chemical Sciences. 2014;5:1142–55.
70. Biradar S, Kangralkar VA, Mandavkar Y, Thakur M, Chougule N. Anti-inflammatory, antiarthritic, analgesic and anti-convulsant activity of cyperus essential oils. Int J Pharm Pharm Sci. 2010;2:112–5.
71. Singh N, Pandey BR, Verma P, Bhalla M, Gilca M. Phyto-pharmacotherapeutics of Cyperus rotundus Linn.(Moha): An overview. Indian Journal of Natural Products and Resources. 2012;3:467–76.
72. Joshi MK, Joshi HB, Joshi KT, Joshi UT. Anticonvulsant Activity of Chloroform Extract of Nelumbo Nucifera. Int. J. of Pharm. Res. Develop. 2010;3:84–90.
73. Pahuja M, Meha J, Reeta KH, Joshi S, Gupta YK. Hydroalcoholic extract of Zizphus jujube ameliorates seizures, oxidative stress, and cognitive impairment in experimental models of epilepsy in rats. Epilepsy &behavior. 2011;21:356–63.
74. Pal DK, Panda C, Sinhababu S, Dutta A, Bhattacharya S. Evaluation of Psychopharmacological effect of petroleum ether extract of Cuscuta reflexa Roxb. Stem in mice. Acta Pol Pharm Drug Res. 2003;60:481–6.
75. Mazumder UK, Gupta M, Pal DK, Bhattacharya S. CNS activities of the methanol extracts of Cuscuta reflexa Roxb. Stem and Corchorous olitorius L. seed in mice. Malaysian J. Pharm. 2005;2:190–198.
76. Pal DK, Sahoo M, Mishra AK. Analgesic and anticonvulsant effects of saponin isolated from the stems of Opuntia vulgaris Mill in mice. Eur. Bull. Drug Res. 2005;13:91–97.
77. Pal DK, Dutta S, Sarkar A. Evaluation of antioxidant activity of the roots of Cyperus rotundus L. Acta Pol. Pharm Drug Res. 2006;68:256–8.
78. Pal DK, Balasaheeb NS, Khatun S, Bandyopadhyay PK. CNS activities of the aqueous extract of Hydrilla verticillata in mice. Nal Prod Sci. 2006;12:44–9.
79. Viswanatha GL, Mohan CG, Shylaja H, Yuvaraj HC, Sunil V. Anticonvulsant activity of 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose isolated from leaves of Mangifera indica. Naunyn Schmiedebergs Arch Pharmacol. 2013;386:599–604.
81. Buisson A, Lakhmeche N, Verrecchia C, Plotkine M, Boulu RG. Nitric oxide: an endogenous anticonvulsant substance. Neuroreport. 1993;4:444–6.
82. Sudha K, Rao AV, Rao A. Oxidative stress and antioxidants in epilepsy. Clin. Chem. 2001;303:19–24.
83. Abhang P, Patil M, Moghe P. Beneficial Effects of Agnihotra on Environment and Agriculture. International Journal of Agricultural Science and Research. 2015;5:111–20.
84. Chunmei L, Myeong-Hyeon W. Nardostachys jatamansi (D. Don) DC prevents LPS-induced inflammation in RAW 264.7 macrophages by preventing ROS production and down-regulating inflammatory gene expression. Food Science and Biotechnology. 2014;23:903–9.
85. Parizadeh MR, Gharib FG, Abbaspour AR, Afshar JT, Mobarhan MG. Effects of aqueous saffron extract on nitric oxide production by two human carcinoma cell lines: Hepatocellular carcinoma (HepG2) and laryngeal carcinoma (Hep2). Avicenna J Phytomed. 2011;1:43–50.
86. Sohn DH, Kim YC, Oh SH, Park EJ, Li X, Lee BH. Hepatoprotective and free radical scavenging effects of Nelumbo nucifera. Phytomedicine. 2003;10:165–9.
87. Yen GC, Duh PD, Su HJ, Yeha CT, Wu CH. Scavenging effects of lotus seed extracts on reactive nitrogen species. Food Chemistry. 2006;94:596–602.
88. Perez-Roses R, Risco E, Vila R, Penalver P, Canigueral S. Inhibitory activity of nine essential oils on nitric oxide production by humanleukocytes. Planta Med. 2009;75:17–26.
89. Nagulendran KR, Velavan S, Mahesh R, Begum VH. In vitro antioxidant activity and total polyphenolic content of Cyperus rotundus rhizomes. J Chem. 2007;4:440–9.
90. Cheng YW, Cheah KP, Lin CW, et al. Myrrh mediates haem oxygenase-1 expression to suppress the lipopolysaccharide-induced inflammatory response in RAW 264.7 macrophages. J Pharmacy and Pharmacology. 2011;63:1211–8.
91. Niranjan R, Kamat PK, Nath C, Shukla R. Evaluation of guggulipid and nimesulide on production of inflammatory mediators and GFAP expression in LPS stimulated rat astrocytoma, cell line (C6). Journal of Ethnopharmacology. 2010;127:625–30.
92. Nishaa S, Vishnupriya M, Sasikumar JM, Hephzibah PC, Gopalakrishnan VK. Antioxidant Activity of Ethanolic Extract of Maranta Arundinacea L Tuberous Rhizomes. Asian J Pharm Clin Res. 2012;5:85–88.
93. Chaitanya KK, Rao KK, Sastry YN, Padal SB, Lakshmi AR, Rao DG. Anti-inflammatory, antioxidant and phytochemical analysis of Mesua ferrea bark extracts. IJCTPR. 2015;3:891–902.
94. Nirmala S, Ahamed HN, Ravichandiran V. Comparative in vitro study on the free radical scavenging capacity of tannin and biflavone fraction from Ficus racemosa Linn and Araucaria bidwilli Hook. International Journal of ChemTech Research. 2011;3:1440–5.
95. Won-Gil S, Hyun-Ock P, Gi-Su O, et al. Inhibitory effects of methanol extract of Cyperus rotundus rhizomes on nitric oxide and superoxide productions by murine macrophage cell line, RAW 264.7 cells. Journal of Ethnopharmacology. 2001;76:59–64.
96. Ngo Bum E, Rakotoniria A, Rakotoniria SV, Herrling P. Effect of cyperus articulates compared to effects of anticonvulsant compounds on the cortical wedge. Journal of Ethnopharmacol. 2003;97:27–34.
97. Chen JK, Chen TT. Chinese Medical Herbology and Pharmacology. City of Industry, USA: Art of Medicine Press; 2003. p. 1031–74.
98. Yuching W. Handbook of Commonly Used Chinese Herbal Prescriptions. Long Beach, USA: Oriental Healing Arts Institute; 1983. p. 104–7.
99. Han BH, Park MH. Folk Medicine. Washington, USA: American Chemical Society; 1986. p. 205–9.
100. Huang KC. The Pharmacology of Chinese Herbs. Boca Raton, USA: CRC Press; 1999. p. 155–8.
101. Park JH, Lee HJ, Koh SB, Ban JY, Seong YH. Protection of NMDA-induced neuronal cell damage by methanol extract of Zizyphi Spinosi Semen in cultured rat cerebellar granule cells. J. Ethnopharmaol. 2004;95:39–45.
102. Jacobo-Herrera NJ, Vartiainen N, Bremner P, Gibbons S, Koistinaho J, Heinrich M. NF-κB modulators from Valeriana officinalis. Phytother Res. 2006;20:917–9.
103. Del Valle-Mojica LM, Ayala-Marin YM, Ortiz-Sanchez CM, Torres-Hernandez BA, Abdalla-Mukhaimer S, Ortiz JG. Selective interactions of Valeriana officinalis extracts and valerenic acid with [3H] glutamate binding to rat synaptic membranes. Evid. Based Complement. Alt. Med. 2011;403591:10.1155/2011/403591..
104. Nieber K, Berger F, Hensel A. Saffron extract and trans-crocetin inhibits excitotoxicity by inhibition of post-synaptically located glutamate receptors in rat brain neurons, Proceedings of the British Pharmacological Society. http://www.pA2online.org/abstracts/Vol10Issue3abst006P.pdf..
105. Berger F, Hensel A, Nieber K. Saffron extract and trans-crocetin inhibit glutamatergic synaptic transmission in rat cortical brain slices. Neuroscience. 2011;180:238–47.
106. Aizenman E, Hartnett KA, Reynolds IJ. Oxygen free radicals regulates NMDA receptor function via a redox modulatory site. Neuron. 1990;5:841–6.
107. Volterra A, Trotti D, Racagni G. Glutamate uptake is inhibited by arachidonic acid and oxygen radicals via two distinct and additive mechanisms. Mol. Pharmacol. 1994;46:986–92.
108. Volterra A, Trotti D, Tromba C, Floridi S, Racagni G. Glutamate uptake inhibition by oxygen free radicals in rat cortical astrocyte. J. Neurosci. 1994;14:2924–32.
109. Wie MB, Won MH, Lee KH, et al. Eugenol protects neuronal cells from excitotoxic and oxidative injury in primary cortical cultures. Neurosci. Lett. 1997;225:93–6.
110. Huang CW, Chow JC, Taid JJ, Wu SN. Characterizing the effects of eugenol on neuronal ionic currents and hyperexcitability. Psychopharmacology. 2012;21:575–87.
111. Lemus-Molina Y, Sanchez-Gomez MV, Delgado-Hernandez R. Matute C. Mangifera indica L. extract attenuates glutamate-induced neurotoxicity on rat cortical neurons. NeuroToxicology. 2009;30:1053–8.
112. Heuberger E, Hongratanaworakit T, Bohm C, Weber R, Buchbauer G. Effects of chiral fragrances on human autonomic nervous system parameters and self-evaluation. Chem Senses. 2001;26:281–92.