1. Kossoff EH, Zupec-Kania BA, Amark PE, et al. Optimal clinical management of children receiving the ketogenic diet: recommendations of the International Ketogenic Diet Study Group. Epilepsia. 2009;50:304–17.
2. Gilbert DL, Pyzik PL, Freeman JM. The ketogenic diet: seizure control correlates better with serum beta-hydroxybutyrate than with urine ketones. J Child Neurol. 2000;15:787–90.
3. Bough KJ, Yao SG, Eagles DA. Higher ketogenic diet ratios confer protection from seizures without neurotoxicity. Epilepsy Res. 2000;38:15–25.
4. Samoilova M, Weisspapir M, Abdelmalik P, Velumian AA, Carlen PL. Chronic in vitro ketosis is neuroprotective but not anti-convulsant. J Neurochem. 2010;113:826–35.
5. Likhodii SS, Musa K, Mendonca A, Dell C, Burnham WB, Cunnane SC. Dietary fat, ketosis, and seizure resistance in rats on the ketogenic diet. Epilepsia. 2000;41:1400–10.
6. Dell CA, Likhodii SS, Musa K, Ryan MA, Burnham WB, Cunnane SC. Lipid and fatty acid profiles in rats consuming different high-fat ketogenic diets. Lipids. 2001;36:373–8.
7. Nylen K, Likhodii SS, Abdelmalik PA, Clarke J, Burnham WM. A comparison of the ability of a 4:1 ketogenic diet and a 6.3:1 ketogenic diet to elevate seizure thresholds in adult and young rats. Epilepsia. 2005;46:1198–204.
8. Innis SM. The role of dietary n-6 and n-3 fatty acids in the developing brain. Dev Neurosci. 2000;22:474–80.
9. Cunnane SC, Musa K, Ryan MA, Whiting S, Fraser DD. Potential role of polyunsaturates in seizure protection achieved with the ketogenic diet. Prostaglandins Leukot Essent Fatty Aci. 2002;67:131–5.
11. Boland LM, Drzewiecki MM. Polyunsaturated fatty acid modulation of voltage-gated ion channels. Cell Biochem Biophys. 2008;52:59–84.
12. Xu XP, Erichsen D, Börjesson SI, Dahlin M, Amark P, Elinder F. Polyunsaturated fatty acids and cerebrospinal fluid from children on the ketogenic diet open a voltage-gated K channel: a putative mechanism of antiseizure action. Epilepsy Res. 2008;80:57–66.
13. De Almeida AC, dos Santos HL, Rodrigues AM, et al. Non-synaptic mechanisms that could be responsible for potential antiepileptic effects of omega-3 fatty acids. Epilepsy Behav. 2012;25:138–40.
14. Fraser DD, Whiting S, Andrew RD, Macdonald EA, Musa-Veloso K, Cunnane SC. Elevated polyunsaturated fatty acids in blood serum obtained from children on the ketogenic diet. Neurology. 2003;60:1026–9.
15. Taha AY, Burnham WM, Auvin S. Polyunsaturated fatty acids and epilepsy. Epilepsia. 2010;51:1348–58.
16. Musto AE, Gjorstrup P, Bazan NG. The omega-3 fatty acid-derived neuroprotectin D1 limits hippocampal hyperexcitability and seizure susceptibility in kindling epileptogenesis. Epilepsia. 2011;52:1601–8.
17. Auvin S. Fatty acid oxidation and epilepsy. Epilepsy Res. 2012;100:224–8.
18. Taha AY, Filo E, Ma DW, McIntyre Burnham W. Dose-dependent anticonvulsant effects of linoleic and alpha-linolenic polyunsaturated fatty acids on pentylenetetrazol induced seizures in rats. Epilepsia. 2009;50:72–82.
19. Voskuyl RA, Vreugdenhil M, Kang JX, Leaf A. Anticonvulsant effect of polyunsaturated fatty acids in rats, using the cortical stimulation model. Eur J Pharmacol. 1998;341:145–52.
20. Flores-Mancilla LE, Hernández-González M, Guevara MA, Benavides-Haro DE, Martínez-Arteaga P. Long-term fish oil supplementation attenuates seizure activity in the amygdala induced by 3-mercap-topropionic acid in adult male rats. Epilepsy Behav. 2014;33:126–34.
21. Willis S, Samala R, Rosenberger TA, Borges K. Eicosapentaenoic and docosahexaenoic acids are not anticonvulsant or neuroprotective in acute mouse seizure models. Epilepsia. 2009;50:138–42.
22. Curatolo N, Lecointe C, Bordet R, et al. Oral administration of docosahexaenoic acid/eicosapentaeinoic acids is not anticonvulsant in rats: implications for translational research. Pediatr Res. 2011;70:584–8.
23. Schlanger S, Shinitzky M, Yam D. Diet enriched with omega-3 fatty acids alleviates convulsion symptoms in epilepsy patients. Epilepsia. 2002;43:103–4.
24. Yoon JR, Lee EJ, Kim HD, Lee JH, Kang HC. Polyunsaturated fatty acid-enriched diet therapy for a child with epilepsy. Brain Dev. 2014;36:163–6.
25. Scorza FA, Cavalheiro EA, Arida RM, et al. Positive impact of omega-3 fatty acid supplementation in a dog with drug-resistant epilepsy: a case study. Epilepsy Behav. 2009;15:527–8.
26. Yuen AW, Sander JW, Fluegel D, et al. Omega-3 fatty acid supplementation in patients with chronic epilepsy: a randomized trial. Epilepsy Behav. 2005;7:253–8.
27. Bromfield E, Dworetzky B, Hurwitz S, et al. A randomized trial of polyunsaturated fatty acids for refractory epilepsy. Epilepsy Behav. 2008;12:187–90.
28. DeGiorgio CM, Miller P, Meymandi S, Gornbein JA. n-3 fatty acids (fish oil) for epilepsy, cardiac risk factors, and risk of SUDEP: clues from a pilot, double-blind, exploratory study. Epilepsy Behav. 2008;13:681–4.
29. Dahlin M, Hjelte L, Nilsson S, Amark P. Plasma phospholipid fatty acids are influenced by a ketogenic diet enriched with n-3 fatty acids in children with epilepsy. Epilepsy Res. 2007;73:199–207.
30. Ben-Ari Y. Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy. Neuroscience. 1985;14:375–403.
31. Stafstrom CE, Thompson JL, Holmes GL. Kainic acid seizures in the developing brain: status epilepticus and spontaneous recurrent seizures. Brain Res Dev Brain Res. 1992;65:227–36.
32. Su SW, Cilio MR, Sogawa Y, Silveira DC, Holmes GL, Stafstrom CE. Timing of ketogenic diet initiation in an experimental epilepsy model. Brain Res Dev Brain Res. 2000;125:131–8.
33. Rogers AE. Nutrition. Baker HJ, Lindsey JR, Weisbroth SH, editors. The Laboratory Rat. Orlando: Academic Press; 1979. p. 123–52.
34. Bough KJ, Schwartzkroin PA, Rho JM. Calorie restriction and ketogenic diet diminish neuronal excitability in rat dentate gyrus in vivo. Epilepsia. 2003;44:752–60.
35. Racine RJ. Modification of seizure activity by electrical stimulation: II. Motor seizure. Electroencephalogr Clin Neurophysiol. 1972;32:281–94.
36. Thio LL, Erbayat-Altay E, Rensing N, Yamada KA. Leptin contributes to slower weight gain in juvenile rodents on a ketogenic diet. Pediatr Res. 2006;60:413–7.
37. Peres RC, Nogueira DB, de Paula Guimarães G, da Costa EL, Ribeiro DA. Implications of ketogenic diet on weight gain, motor activity and cicatrization in Wistar rats. Toxicol Mech Methods. 2013;23:144–9.
38. Wachira JK, Larson MK, Harri WS. n-3 Fatty acids affect haemostasis but do not increase the risk of bleeding: clinical observations and mechanistic insights. Br J Nutr. 2014;111:1652–62.
39. Calon F. Omega-3 polyunsaturated fatty acids in Alzheimer’s disease: key questions and partial answers. Curr Alzheimer Res. 2011;8:470–8.
40. von Geldern G, Mowry EM. The influence of nutritional factors on the prognosis of multiple sclerosis. Nat Rev Neurol. 2012;8:678–89.
41. Gillies D, Sinn JKH, Lad SS, Leach MJ, Ross MJ. Polyunsaturated fatty acids (PUFA) for attention deficit hyperactivity disorder (ADHD) in children and adolescents. Cochrane Database Syst Rev. 2012;7. CD007986
42. Salvati S, Attorri L, Avellino C, Di Biase A, Sanchez M. Diet, lipids and brain development. Dev Neurosci. 2000;22:481–7.
43. Young C, Gean PW, Chiou LC, Shen YZ. Docosahexaenoic acid inhibits synaptic transmission and epileptiform activity in the rat hippocampus. Synapse. 2000;37:90–4.
44. Taha AY, Trepanier MO, Ciobanu FA, et al. A minimum of 3 months of dietary fish oil supplementation is required to raise amygdaloid afterdischarge seizure thresholds in rats-implications for treating complex partial seizures. Epilepsy Behav. 2013;27:49–58.
45. Yehuda S, Carasso RL, Mostofsky DI. Essential fatty acid preparation (SR-3) raises the seizure threshold in rats. Eur J Pharmacol. 1994;254:193–8.
46. Taha AY, Baghiu BM, Lui R, Nylen K, Ma DW, Burnham WM. Lack of benefit of linoleic and alpha-linolenic polyunsaturated fatty acids on seizure latency, duration, severity or incidence in rats. Epilepsy Res. 2006;71:40–6.
47. Porta N, Bourgois B, Galabert C, et al. Anticonvulsant effects of linolenic acid are unrelated to brain phospholipid cell membrane compositions. Epilepsia. 2009;50:65–71.
48. Bough KJ, Valiyil R, Han FT, Eagles DA. Seizure resistance is dependent upon age and calorie restriction in rats fed a ketogenic diet. Epilepsy Res. 1999;35:21–8.